N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
- Product Name
- N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
- CAS No.
- 945128-26-7
- Chemical Name
- N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
- Synonyms
- ML249;CYM5541;CYM-5541;CID-17253208;CYM 5541(ML-249);CYM-5541;CYM 5541;ML-249;ML 249;ML249;N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide;N,N-Dicyclohexyl-5-cyclopropylisoxazole-3-carboxamide;3-Isoxazolecarboxamide, N,N-dicyclohexyl-5-cyclopropyl-;N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide
- CBNumber
- CB72750683
- Molecular Formula
- C19H28N2O2
- Formula Weight
- 316.44
- MOL File
- 945128-26-7.mol
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Property
- Boiling point:
- 503.1±38.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- form
- powder
- pka
- -2.57±0.20(Predicted)
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0680
- Product name
- CYM-5541
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $123
- Updated
- 2024/03/01
- Product number
- SML0680
- Product name
- CYM-5541
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $154.4
- Updated
- 2024/03/01
- Product number
- 15190
- Product name
- CYM 5541
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 15190
- Product name
- CYM 5541
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- 15190
- Product name
- CYM 5541
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $211
- Updated
- 2024/03/01
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Chemical Properties,Usage,Production
Description
The sphingosine 1-
Uses
CYM 5541, is a selective allosteric agonist of SAR and S1P3 receptors.
Biochem/physiol Actions
CYM-5541 is an allosteric agonist selective for the Sphingosine 1-phosphate (S1P) S1P3 receptor subtype. CYM-5541 occupies a different chemical space in the ligand binding pocket of S1P3 than S1P does, a lower hydrophobic region around transmembrane helix TM6. CYM-5541 shows great selectivity and stability with an EC50 of between 72 and 132 nM compared to S1P1 EC50 > 10 μM, S1P2 EC50 > 50 μM, S1P4 EC50 > 50 μM, and S1P5 EC50 > 25 μM and no significant activities for a panel of 55 GPCRs, ion channels, and transporters.
storage
Store at +4°C
References
1) Guerrero?et al.?(2011),?Probe Development Efforts for an Allosteric Agonist of Sphingosine 1-phosphate Receptor 3 (S1P3); Probe Reports from the NIH Molecular Libraries Program 2) Jo?et al.?(2012),?Novel Selective Allosteric and Bitopic Ligands for the S1P3 Receptor; ACS Chem. Biol.?7?1975